30 Jun 2020 gp130 is a potential therapeutic target to improve heart regeneration after cardiac injury. Clinical Perspective. What Is New? gp130 (glycoprotein

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Author T Taga 1 Affiliation 1 Institute for Molecular 9 gp130 cytokines as agents of local control of PTH action. gp130 is a receptor subunit capable of intracellular signaling that is required for the cellular action of the IL-6 family of cytokines. The most well-known are interleukin IL-6 and IL-11, LIF, CT-1, OSM, and ciliary neurotrophic factor. 2016-01-01 2020-06-30 gp130 Inhibitor, SC144 - Calbiochem; Synonym: gp130 Inhibitor, SC144 - Calbiochem, SC144; Linear Formula: C16H11FN6O · xHCl; find Sigma-Aldrich-5.06387 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. Interactions IL6ST (Interleukin 6 Cytokine Family Signal Transducer) is a Protein Coding gene. Diseases associated with IL6ST include Hyper-Ige Recurrent Infection Syndrome 4, Autosomal Recessive and Stuve-Wiedemann Syndrome.Among its related pathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Physiological and Pathological Hypertrophy of the Heart.

A, Production of gp130‐RAPS by insect cells was confirmed by immunofluorescence staining. Noninfected (top) and infected (bottom) Sf9 cells were fixed, incubated with a specific anti‐NIASF antibody (Mab529), and visualized using a fluorescein isothiocyanate–conjugated anti‐mouse antibody. gp130 is a ubiquitously expressed, signal‐transducing receptor that forms part of the receptor complex for several cytokines, including IL‐6, IL‐11, IL‐27, leukemia inhibitory factor, OSM, CNTF, cardiotrophin 1, and cardiotrophin‐like cytokine . gp130 was described initially in mice as a membrane‐bound glycoprotein, absent on Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors.It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. Glycoprotein gp130 has a molecular mass of 130–150 kDa; gp130 has the alternative names IL-6Rβ, CD130, and IL-6 signal transducer.

View R&D Systems research products for gp130. 0.1 - 8 ng/mL (Cell Culture Supernates), 0.3 - 16 ng/mL (Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma)

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Cell proliferation was determined using a Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy Jia Wei1,2, Ling Ma2, Yi-Hui Lai3, Ruijie Zhang2, Huameng Li4, Chenglong Li5 and Jiayuh Lin2* Abstract Background: Interleukin-11 (IL-11), a dominant IL-6 family cytokine, is involved in tumorigenesis, tumor progression and differentiation in colon cancer cells. 2020-07-27 · To further explore the role of gp130 in heart regeneration, we generated gp130 fl/fl mice, in which the 5′LoxP element was inserted into intron 16 to 17 and the 3′LoxP element into downstream of 3′-untranslated region; and conditional ablation of gp130 in cardiomyocytes was achieved by crossing Myh6-MerCreMer mice with gp130 fl/fl mice (Myh6-gp130 −/−) . gp130 deletion in gp130 is a ubiquitously expressed, signal‐transducing receptor that forms part of the receptor complex for several cytokines, including IL‐6, IL‐11, IL‐27, leukemia inhibitory factor, OSM, CNTF, cardiotrophin 1, and cardiotrophin‐like cytokine . gp130 was described initially in mice as a membrane‐bound glycoprotein, absent on Johana & Narquoise - Geispolsheim - GP130 GP130-KO cells transfected with GP130-p.N404Y were unable to up-regulate fibrinogen after stimulation with IL-6, whereas transfection of GP130-WT restored the response .

GP130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines (1-3). The binding of a ligand to its receptor induces the dimerization of GP130, leading to activation of the Jak tyrosine kinase and to tyrosine phosphorylation of GP130. INTRODUCTION: Ubiquitously expressed in the human body, glycoprotein 130 (gp130) is a shared subunit of receptor complexes for at least nine cytokines (IL-6, OSM, LIF, IL-11, CNTF, CLC, IL-27, CT-1, and NP) that mediate highly diverse biological processes.
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Mother: Karin Persdotter Born: 1854, Sweden Died: 1914, Sweden.

View R&D Systems research products for gp130. 0.1 - 8 ng/mL (Cell Culture Supernates), 0.3 - 16 ng/mL (Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma) ab217671 Anti-CD130 (gp130) antibody [EPR21732] was shown to specifically react with CD130 (gp130) in wild-type A549 cells.
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Gp130. Gene. gp130. Organism. Homo sapiens (Human) Status. Unreviewed-Annotation score: -Experimental evidence at transcript level i. Names & Taxonomy i. Protein names i: Submitted name: Gp130 Imported. Gene names i: Name:gp130

Gp130. Gene. gp130. Organism.

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In this Review, we explore how gp130 signaling controls disease progression and examine why IL-6 has a special role among these cytokines as an inflammatory

Glycoprotein gp130 has a molecular mass of 130–150 kDa; gp130 has the alternative names IL-6Rβ, CD130, and IL-6 signal transducer.